en بیوشیمی Biochemistry Research Article Research Article <span style="font-size:10pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Background:</b> Diabetic nephropathy is a major cause of kidney failure. The current study aimed to measure serum and urine albumin as well as other biochemical markers in individuals with type 2 diabetic nephropathy and to identify quick diagnostic approaches in these patients.&nbsp;<br> <b>Method</b>: The case-control study consisted of 40 patients with diabetic nephropathy and 40 diabetic patients without nephropathy. After assessing the biochemichal and clinical parameters, based on the ratio of random urine albumin to creatinine, patients were separated into two groups: patients with or without albuminuria. SPSS v18 software was used to analyze the results.</span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Results:</b> In diabetic patients, the levels of urea, creatinine, uric acid were significantly higher in comparison to the control group and were 64.68&plusmn;46.84, 2.01&plusmn;1.82, 5.35&plusmn;2.23 respectively. The average content of serum albumin in diabetic patients with nephropathy was notably lower compared to non-nephropathy patients (3.74&plusmn;0.88. and 4.35&plusmn;0.28) (p < 0.05). In diabetic nephropathy patients, urinary albumin had a direct relationship with serum creatinine level (r=0.347, p=0.028). In the control group, it was possible to check the status of serum albumin by measuring the level of creatinine (r = -0.305, p = 0.056), urea (r = -0.333, p = 0.036) and HbA1C (r = -0.376, p = 0.017).</span></span></span><br> <b><span style="font-size:10.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""> The results revealed that high level of urinary albumin in patients with diabetic nephropathy has a direct association with the serum creatinine level, indicating a helpful index in the evaluation of nephropathy patients with albuminuria. However, further studies with a larger number of participants is required.</span></span></span><br> &nbsp; Type 2 diabetes, Nephropathy patients, Non-nephropathy patients, Biochemical indicators 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1188-1&slc_lang=en&sid=1 Alaa Kazem 100319475328460032344 100319475328460032344 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Azad Reza Mansurian 100319475328460032345 100319475328460032345 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Golam Reza Vaghari 100319475328460032346 100319475328460032346 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Seyed Mostafa Mir 100319475328460032347 100319475328460032347 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Fatemeh Mohammadzadeh msoheila66@yahoo.com 100319475328460032348 100319475328460032348 Yes Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran